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Oncology / Immunology
Biologics
Platform

Membrane protein degradation SureTAC™ Hard-to-drug target



Laigo Bio is pioneering a targeted membrane protein degradation platform to address oncology, autoimmune, and inflammatory disorders.

Our proprietary SureTAC™ product uniquely leverages the proximity between E3 ligases and specific targets, inducing ubiquitination and subsequent lysosomal degradation.

The unique combination of E3 ligase and non-blocking antibodies enables selective degradation of hard-to-drug targets in specific cell types, independently of epitope target recognition.


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Neill Moray Mackenzie
Partner & EIR


Neill Moray Mackenzie is an internationally networked pharmaceutical executive and a serial entrepreneur with extensive operational, commercial, licensing and R&D background in academia, pharma and Biotech companies. Over the last 25 years, after a career in pharma at Wellcome plc, Dr. Mackenzie has served on the boards of Immetacyte Ltd (now Instil Inc.) as co-founder, Chairman and CBO, Trimunocor Ltd. as co-founder and CEO, Biotecnol Ltd. as CBO, Cellular therapeutics Ltd., as CBO, CMP Therapeutics Ltd. as CEO, Roji Ltd. as founder and CEO, Medigene AG (listed on the German Börse) as Senior Vice President, Business Development and Commercial Strategy, Avidex Ltd. (now Immunocore Ltd) as CBO, Oxford BioMedica plc (listed on the LSE), and BioMedica Inc. as co-founder and EVP of Business Development and Corporate Strategy, and with Cambridge Genetics Ltd. as co-founder and CEO.





Related News

02/08/2022 Laigo Bio

Oncode Institute and ArgoBio launch Laigo Bio, a targeted protein degradation biotech with programs in oncology and neurological disorders

www.laigobio.com A collaboration for the creation of a company specialized in the development of a new biological approach for the treatment of cancer and neurological disorders. Argobio and the Oncode Institute will support the company's development to Series A financing. Utrecht (Netherlands), and Paris (France), February 08th 2022 - ArgoBio and Oncode Institute have teamed up with Oncode Investigator Madelon Maurice, researcher and group leader at UMC Utrecht, to launch Laigo Bio, a new company in the emerging field of target protein degradation. The company has additionally secured funding from Oncode Bridge Fund and ArgoBio to further develop its proprietary pipeline of targeted immunotherapies SureTACsR. The SureTACsR technology platform is a novel approach in membrane protein degradation, applicable to a broad scope of disease applications. The primary focus lies in the area of oncology, but with parallel programs in neuro-inflammation and neuro degenerative diseases. In contrast to other small molecule approaches, this results in an efficient and sustained degradation of target receptors, potentially resulting in superior efficacy in the clinic than modalities currently being employed by other emerging protein degradation technologies. Initially driven by Madelon Maurice, who will join as the Principal Investigator, Laigo Bio is gearing up for preclinical lead development in the coming months, generating proprietary biologics for a selection of targets to showcase its potential. Laigo Bio receives strong support from seasoned entrepreneurs Neill Moray Mackenzie at ArgoBio and Emil Pot at Oncode, who will prepare the company for a Series A investment round as it aims to initiate its first clinical studies in 2025. Dr. Neill Moray Mackenzie at ArgoBio is a veteran of the IO field and Mr Emil Pot is an IP & business development expert at Oncode with 25 years of experience in life sciences. Chris De Jonghe, Valorization Director of Oncode Institute, said: “SureTACsR is building on the innovative ideas that Dr. Maurice has initially validated with the support of Oncode’s Technology Development Fund. With the foundation of Laigo Bio, another exciting step forward is made towards the translation of Dr. Maurice’s innovations into effective, and tailored therapies for cancer patients. We are thrilled to join forces with ArgoBio in this initial seed round and consider it as a token of great confidence in the potential of this platform technology.” Madelon Maurice of the UMC Utrecht, said:“We are extremely happy that ArgoBio is supporting my long-standing research here at the UMC Utrecht on how to interfere with signalling alterations that drive oncogenesis and bringing a team of experienced scientists and entrepreneurs to help with its translation to the clinic.” Dr. Neill Moray Mackenzie of ArgoBio, said: “This is exactly why we put ArgoBio together last year – to fund these early-stage opportunities. I am especially pleased that Madelon Maurice, a renowned KOL in the field, is leading this novel approach to protein degradation which has great potential to open up a completely new biology in the field of cancer therapy.” Shobhit Dhawan of Oncode Bridge Fund, said: “Targeted protein degradation is an exciting space and has gained validation in clinical studies with many players now entering the field. One key differentiator here is sustained degradation of cell membrane bound proteins with a biologic, which is a very novel approach, and we believe holds a lot of promise in oncology and many neurological indications. We look forward to supporting Madelon, Neill and Emil in their journey at Laigo Bio.”


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